The ability of the mesocortical dopamine system to operate in distinct temporal modes

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Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling.

In vivo extracellular recording studies have traditionally shown that dopamine (DA) transiently inhibits prefrontal cortex (PFC) neurons, yet recent biophysical measurements in vitro indicate that DA enhances the evoked excitability of PFC neurons for prolonged periods. Moreover, although DA neurons apparently encode stimulus salience by transient alterations in firing, the temporal properties ...

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ژورنال

عنوان ژورنال: Psychopharmacology

سال: 2006

ISSN: 0033-3158,1432-2072

DOI: 10.1007/s00213-006-0527-8